{"product_id":"yy1-rabbit-monoclonal-antibody-mb66406","title":"YY1 Rabbit Monoclonal Antibody-MB66406","description":"\u003cp\u003eYY1 Rabbit Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66406-50, MB66406-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P25490\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IP\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/500 - 1\/1000), IP (1\/10 - 1\/50)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site.\u003cbr\u003e\nBinds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity.\u003cbr\u003e\nThe effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes.\u003cbr\u003e\nIts activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression.\u003cbr\u003e\nFor example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence.\u003cbr\u003e\nActs synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.\u003cbr\u003e\nBinds to SMAD binding elements (SBEs) (5'-GTCT\/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions.\u003cbr\u003e\nMay play an important role in development and differentiation. Proposed to recruit the PRC2\/EED-EZH2 complex to target genes that are transcriptional repressed.\u003cbr\u003e\nInvolved in DNA repair.\u003cbr\u003e\nIn vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation . \u003cbr\u003e\nProposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was purified by immunogen affinity chromatography.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of YY1 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of YY1 expression in K562 (A), rat brain (B), C6 (C), NIH3T3 (D), Hela (E) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 65 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: INO80S; Transcriptional repressor protein YY1; Delta transcription factor; INO80 complex subunit S; NF-E1; Yin and yang 1; YY-1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human YY1\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42906360873139,"sku":"MB66406-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42906360905907,"sku":"MB66406-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_b90e97c5-a852-4576-9834-12bff2f403e8.jpg?v=1702918664","url":"https:\/\/afsbio.com\/products\/yy1-rabbit-monoclonal-antibody-mb66406","provider":"AFSBio Inc.","version":"1.0","type":"link"}