{"product_id":"zap70-monoclonal-antibody-bt-mca2248","title":"ZAP70 Monoclonal Antibody - BT-MCA2248","description":"\u003cp\u003eZAP70 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2248-50, BT-MCA2248-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ZAP70\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6D9C2\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: ZAP70\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human ZAP70 (AA: 169-390) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 69.9kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P43403\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SRK, STD, TZK, STCD, IMD48, ADMIO2, ZAP-70\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 7535\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238404972723,"sku":"BT-MCA2248-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238405005491,"sku":"BT-MCA2248-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_83f80b7d-eb1b-4f38-9d93-86d6943a99b8.png?v=1769380121","url":"https:\/\/afsbio.com\/products\/zap70-monoclonal-antibody-bt-mca2248","provider":"AFSBio Inc.","version":"1.0","type":"link"}