{"product_id":"zap70-polyclonal-antibody-e-ab-60677","title":"ZAP70 Polyclonal Antibody - E-AB-60677","description":"\u003cp\u003eZAP70 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-60677-60, E-AB-60677-120, E-AB-60677-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ZAP70\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ZAP70; ADMIO2; IMD48; SRK; STCD; STD; TZK; ZAP-70\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Immunology,Signal Transduction,Tags and Cell Markers\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P43403\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human ZAP70\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IF 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 35kDa\/55kDa\/69kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 70KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146101096627,"sku":"E-AB-60677-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146101129395,"sku":"E-AB-60677-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146101162163,"sku":"E-AB-60677-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_f051e209-6ba0-4237-a614-bd7d798f54c9.png?v=1710290905","url":"https:\/\/afsbio.com\/products\/zap70-polyclonal-antibody-e-ab-60677","provider":"AFSBio Inc.","version":"1.0","type":"link"}