{"product_id":"zcchc3-polyclonal-antibody-e-ab-67087","title":"ZCCHC3 Polyclonal Antibody - E-AB-67087","description":"\u003cp\u003eZCCHC3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-67087-60, E-AB-67087-120, E-AB-67087-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ZCCHC3\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ZCCHC3; C20orf99\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9NUD5\u003c\/p\u003e\n\n\u003cp\u003eBackground: Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58\/RIG-I, IFIH1\/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58\/RIG-I and IFIH1\/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of DDX58\/RIG-I and IFIH1\/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58\/RIG-I and IFIH1\/MDA5.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human ZCCHC3 (NP_149080.2).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IF 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43144083800243,"sku":"E-AB-67087-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43144083833011,"sku":"E-AB-67087-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43144083865779,"sku":"E-AB-67087-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_7a27293d-c5e6-4ad0-938f-d3f9488ad341.png?v=1710246155","url":"https:\/\/afsbio.com\/products\/zcchc3-polyclonal-antibody-e-ab-67087","provider":"AFSBio Inc.","version":"1.0","type":"link"}