{"product_id":"zip4-rabbit-polyclonal-antibody-es6734","title":"ZIP4 Rabbit Polyclonal Antibody - ES6734","description":"\u003cp\u003eZIP4 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6734-50, ES6734-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the zinc\/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: SLC39A4, ZIP4, Zinc transporter ZIP4, Solute carrier family 39 member 4, Zrt- and Irt-like protein 4, ZIP-4\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human SLC39A4. AA range:431-480\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: ZIP4\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: ZIP4 Polyclonal Antibody detects endogenous levels of ZIP4 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 68kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Mineral absorption, Alzheimer disease, Parkinson disease\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ) [MIM: 201100]. AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinicals features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal\u003cbr\u003e\nFunction: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability\u003cbr\u003e\nSimilarity: Belongs to the ZIP transporter (TC 2.A.5) family\u003cbr\u003e\nSubcellular Location: Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability\u003cbr\u003e\nTissue Specificity: Highly expressed in kidney, small intestine, stomach, colon\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane, Multi-pass membrane protein Recycling endosome membrane, Multi-pass membrane protein Colocalized with TFRC in the recycling endosomes Cycles between endosomal compartments and the plasma membrane in response to zinc availability\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: SLC39A4\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Zinc transporter ZIP4\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q78IQ7\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313636397235,"sku":"ES6734-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313636430003,"sku":"ES6734-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/zip4-rabbit-polyclonal-antibody-es6734","provider":"AFSBio Inc.","version":"1.0","type":"link"}