{"product_id":"znf395-polyclonal-antibody-e-ab-13288","title":"ZNF395 Polyclonal Antibody - E-AB-13288","description":"\u003cp\u003eZNF395 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-13288-60, E-AB-13288-120, E-AB-13288-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ZNF395\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: DKFZp434K1210; HD gene regulatory region binding protein 2; HD gene regulatory region-binding protein 2; HD-regulating factor 2; HDBP-2; HDBP2; HDRF-2; Huntington disease gene regulatory region-binding protein 2; Huntington's disease gene regulatory region binding protein 2; Papillomavirus regulatory factor 1; papillomavirus regulatory factor PRF 1; Papillomavirus-binding factor; PBF; PRF-1; PRF1; PTTG1IP; Si-1-8-14; Zinc finger protein 395; ZN395; znf395\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling, Microbiology\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9H8N7\u003c\/p\u003e\n\n\u003cp\u003eBackground: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF395 (Zinc finger protein 395), also known as PBF (Papillomavirus-binding factor) and HDBP2 (Huntington disease gene regulatory region-binding protein 2), is a 513 amino acid protein that contains one C2H2-type zinc finger. ZNF395 binds to the 3’-CCGG-5’ sequence within the papillomavirus promoter adjacent to a RUNX1-binding motif. It has also been established that ZNF395 binds to a seven base pair region within the Huntington's disease (HD) gene promoter, an essential element for HD gene expression. ZNF395 is widely expressed and probably shuttles between the nucleus and cytoplasm.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.8 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide of human ZNF395\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"200μL","offer_id":43124123402419,"sku":"E-AB-13288-200","price":558.6,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43124123435187,"sku":"E-AB-13288-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"60μL","offer_id":43124123467955,"sku":"E-AB-13288-60","price":200.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_863dbd90-e034-4aab-80af-f196736108af.png?v=1709724285","url":"https:\/\/afsbio.com\/products\/znf395-polyclonal-antibody-e-ab-13288","provider":"AFSBio Inc.","version":"1.0","type":"link"}