{"product_id":"znf451-polyclonal-antibody-e-ab-66483","title":"ZNF451 Polyclonal Antibody - E-AB-66483","description":"\u003cp\u003eZNF451 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-66483-60, E-AB-66483-120, E-AB-66483-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ZNF451\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ZNF451; COASTER; dJ417I1.1\u003c\/p\u003e\n\n \n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9Y4E5\u003c\/p\u003e\n\n\u003cp\u003eBackground: E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I\/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human ZNF451 (NP_001026794.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:200-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 63kDa\/115kDa\/121kDa\u003c\/p\u003e\n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43135936233651,"sku":"E-AB-66483-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43135936266419,"sku":"E-AB-66483-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43135936299187,"sku":"E-AB-66483-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8d54c3fb-32bf-4091-9aa3-75134a9939d7.png?v=1709986777","url":"https:\/\/afsbio.com\/products\/znf451-polyclonal-antibody-e-ab-66483","provider":"AFSBio Inc.","version":"1.0","type":"link"}