{"product_id":"znt8-polyclonal-antibody-bs62515","title":"ZNT8 Polyclonal Antibody-BS62515","description":"\u003cp\u003eZNT8 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS62515-50, BS62515-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q8IWU4\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Zinc, an essential element required for cell proliferation and differentiation, plays a role in a diverse array of cellular functions (such as neuroregulation) and acts as a cofactor for numerous enzymes and transcription factors. The zinc transporter (ZnT) family regulates the supply of zinc within cells, and its members commonly contain six membrane-spanning domains, a large histidine-rich intracellular loop and a C-terminal tail. ZnT-8 (zinc transporter 8), also known as SLC30A8 (solute carrier family 30 member 8), is a 369 amino acid multi-pass membrane protein that belongs to the ZnT family and is a major autoantigen in type I diabetes. Expressed specifically in pancreas islet cells, ZnT-8 functions as a zinc-efflux transporter that facilitates the accumulation of zinc in intracellular vesicles and is essential for the zinc-dependent maturation of Insulin within pancreatic cells. Multiple isoforms of ZnT-8 exist due to alternative splicing events.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: ZNT8 polyclonal antibody detects endogenous levels of ZNT8 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of ZNT8 polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLaneA:H9C2 whole cell lysate\u003cbr\u003e\nLaneB:K562 whole cell lysate\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 41 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Zinc transporter 8; ZnT-8; Solute carrier family 30 member 8; SLC30A8; ZNT8\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human ZNT8.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42910448976051,"sku":"BS62515-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42910449008819,"sku":"BS62515-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_0cc01fc2-fe7f-447d-9fb3-51a2f52de3ab.jpg?v=1703092613","url":"https:\/\/afsbio.com\/products\/znt8-polyclonal-antibody-bs62515","provider":"AFSBio Inc.","version":"1.0","type":"link"}