Product Description

Catenin-β (phospho-T41/S45) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5057-50, BS5057-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites resμlt in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Catenin β, Cateninβ, Catenin beta-1, Beta-catenin, CTNNB1, CTNNB, ORF Names: OK/SW-cl.35, PRO2286

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: A phospho specific peptide corresponding to residues surrounding threonine 41 and 45 of Human Catenin-β.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-beta-catenin (T41/S45) polyclonal antibody detects endogenous levels of beta-catenin protein only when phosphorylated at Thr41/S45.

Molecular Weight: ~ 92 kDa

Pathway: Hypoxia Signaling, Wntβ catenin signaling，Contribution of ECM and Cytoskeletal Factors to EMT, Contribution of Soluble Factors to EMT, hippo Signaling, Adherens Junction signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P35222

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only