GFRα-1 (K90) Polyclonal Antibody-BS1141

GFRα-1 (K90) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS1141-50, BS1141-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P56159

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGFβ superfamily of growth factors. Three receptors for these factors, GFRα-1 (also designated GDNFR-α, RETL1 or TrnR-1), GFRα-2 (also designated GDNFR-β, RETL2, NTNR-α or TrnR-2) and GFRα-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFRα-1 and GFRα-2 have been shown to mediate the GDNF-dependent and NTN-dependent phosphorylation and activation of the tyrosine kinase Ret. GFRα-3 is expressed only during development.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of GFRα-1 (K90) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 51 kDa

Specificity: GFR α-1 (K90) polyclonal antibody detects endogenous levels of GFR α-1 protein.

Alternative Name: GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1; GFRA1; GDNFRA; RETL1; TRNR1; GFRα1; GFR α1; GFR α-1; GFR α1

Immunogen: Synthetic peptide, corresponding to amino acids 50-100 of Human GFRα-1.

Conjugate: Unconjugated

Modification: Unmodified