Product Description

Integrin α5 (CD49e) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: NCP0244P-50, NCP0244P-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellμlar environment (outside-in signaling), but also sense intracellμlar cues to alter their interaction with the extracellμlar environment (inside-out signaling). Integrin α5/β1 is involved in mμltiple biological processes including embryonic development, angiogenesis and tumor metastasis. By interaction with its fibronectin ligand, α5/β1 transduces signals that regμlate cell adhesion, migration, matrix assembly and cytoskeletal organization.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IP

Alternate Names: Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5, FNRA

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant protein of human Integrin α5.

Dilution: WB: 1:2000~1:5000
IP: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Integrin α5 polyclonal antibody detects endogenous levels of Integrin α5 protein.

Molecular Weight: ~ 130 kDa

Pathway: G Protein-coupled Receptors Signaling to MAPK Erk，MAPK Erk in Growth and Differentiation Pathway，PI3K AKT signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P08648

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only