Product Description

PLC β3 (phospho-S537) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4864-50, BS4864-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: A total of eight mammalian PLC isozymes have been described (PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1 and PLC δ2) with molecμlar weights ranging from 85 to 150 kDa. The γ-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two γ-type enzymes, but not the β and δ isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC β1, PLC β2 and PLC β3 is mediated by the α subunits of the Gq class of heterotrimeric G proteins and by certain βγ G protein subunits. The regμlatory mechanisms for PLC δ1 and PLC δ2 are as yet not resolved.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase β-3, Phosphoinositide phospholipase C-β-3, Phospholipase C-β-3, PLC-β3, 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase beta-3, Phosphoinositide phospholipase C-beta-3, Phospholipase C-beta-3, PLC-beta-3, PLCB3, PLCβ3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human PLC β3 around the phosphorylation site of Serine 537.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-PLC β3 (S537) polyclonal antibody detects endogenous levels of PLC β3 protein only when phosphorylated at Ser537.

Molecular Weight: ~ 150 kDa

Pathway: Phosphoinosotode Signaling, Phospholipase Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q01970

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only