Product Description

RARγ Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: GCP01-50, GCP01-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Nuclear retinoic acid (RA) receptors (RARs) consist of three subtypes encoded by separate genes: α (NR1B1), β (NR1B2), and γ (NR1B3). For each subtype, there are at least two isoforms, which are generated by differential promoter usage and alternative splicing and differ only in their N-terminal regions. Retinoids, which are metabolites of vitamin A, serve as ligands for RARs. RARs function as ligand-dependent transcriptional regμlators and are found to be heterodimerized with retinoid X receptors (RXRs). These transcriptionally active dimers regμlate the expression of genes involved in cellμlar differentiation, proliferation, and apoptosis. Consequently, RARs play critical roles in a variety of biological processes, including development, reproduction, immunity, and organogenesis. RAR mutations, fusion proteins, altered expression levels, or aberrant post-translational modifications resμlt in mμltiple diseases due to altered RAR function and disruption of homeostasis.

Category: Primary Antibody

Reactivity: Human, Pig

Host: Rabbit

Applications: WB

Alternate Names: Retinoic acid receptor gamma, RAR-gamma, Nuclear receptor subfamily 1 group B member 3, RARG, NR1B3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human RARγ.

Dilution: WB: 1:5000~1:10000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: RARγ polyclonal antibody detects endogenous levels of RARγ protein.

Molecular Weight: ~ 60 kDa

Pathway: Wntβ catenin signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P13631

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only