Hepatotoxicity Service
Proprietary assays detect early signals of intrinsic and idiosyncratic toxicity.
ENGINEERED LIVER MODEL FOR PREDICTIVE TOXICOLOGY
Our supplier, Lena Biosciences' proprietary assays scan through cellular vulnerabilities to find the origin of toxicity in a drug metabolism-competent 3D, MPS human liver model
STRUCTURALLY SIMILAR DRUG PAIR
Adjunctive therapies for idiopathic Parkinson’s disease
Adjunctive therapies for idiopathic Parkinson’s disease
Tolcapone
BOXED WARNING
Risk of potentially fatal, acute fulminant liver failure
Entacapone
Postmarketing Reports
Hepatitis with mainly cholestatic features
BOXED WARNING
Risk of potentially fatal, acute fulminant liver failure
- Has a potential reactive metabolite
- Almost completely metabolized prior to excretion
- Excretion: urine (60%) and feces (40%)
Entacapone
Postmarketing Reports
Hepatitis with mainly cholestatic features
- Almost completely metabolized prior to excretion
- Excretion: feces (90%) and urine (10%)
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