Product Description

μlK1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS91404-50, BS91404-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regμlate the formation of autophagophores, the precursors of autophagosomes. Part of regμlatory feedback loops in autophagy: acts both as a downstream effector and negative regμlator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regμlator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regμlate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granμle cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regμlate autophagy.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Serine/threonine-protein kinaseμlK1, Autophagy-related protein 1 homolog (ATG1, Hatg1, Unc-51-like kinase 1,μlK1, KIAA0722

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to HumanμlK1.

Dilution: WB:1:500-1:1, 000
IHC:1:50-1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: μlK1 polyclonal antibody detects endogenous levels ofμlK1 protein.

Molecular Weight: ~ 150 kDa

Pathway: PI3K AKT signaling, MTOR signaling,

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

SwissProt: O75385

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only