Product Description

2A5B Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10223-50, ES10223-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein . at AA range: 160-240

Isotype: IgG

Target: 2A5B,

Specificity: 2A5B Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Highest expression in brain.

Observed Band (KD): 54kD

Fields: mRNA surveillance pathway, Sphingolipid signaling pathway, Oocyte meiosis, PI3K-Akt signaling pathway, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Human papillomavirus infection

Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. induction:By retinoic acid; in neuroblastoma cell lines. PTM: At least isoform Beta-1 is phosphorylated on serine residues. Similarity: Belongs to the phosphatase 2A regulatory subunit B56 family. Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. tissue sp

Subcellular Location: Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: PPP2R5B

Protein Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform, PP2A B subunit isoform B'-beta, PP2A B subunit isoform B56-beta, PP2A B subunit isoform PR61-beta, PP2A B subunit iso

Human Gene ID: 5526

Human SwissProt Number: Q15173

Research Use Only