3HAO Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA30917-50, RA30917-100
Citations, Manuals and MSDS Available upon request.
Background: 3-hydroxyanthranilate 3,4-dioxygenase (HAAO) Homo sapiens 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008],
Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000
Applications: WB; ELISA
Species Cross-Reactivity: Human; Mouse; Rat
GeneID (Human): 23498
Protein MW (KDa): 31
SWISS: P46952
Source: Rabbit
Research Use Only