Product Description

7B2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES9904-50, ES9904-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. [provided by RefSeq, Jul 2016],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 90-170

Isotype: IgG

Target: SCG5

Specificity: 7B2 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Brain, Pancreas, Pituitary,

Observed Band (KD): 23kD

Function: Function: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro
PTM: Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides
PTM: Sulfated on tyrosine residues
Similarity: Belongs to the 7B2 family
Subcellular Location: Neuroendocrine and endocrine secretory granules
Subunit: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages

Subcellular Location: Secreted Neuroendocrine and endocrine secretory granules

Storage and Stability: -20°C/1 year

Gene Name: SCG5 SGNE1

Protein Name: Neuroendocrine protein 7B2 (Pituitary polypeptide) (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide, C-terminal peptide]

Mouse SwissProt Number: P12961

Rat SwissProt Number: P27682

Research Use Only