Product Description

ABCA6 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1561-50, ES1561-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24 and may play a role in macrophage lipid homeostasis. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: ABCA6, ATP-binding cassette sub-family A member 6

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from ABCA6. at AA range: 1180-1260

Isotype: IgG

Target: ABCA6

Specificity: ABCA6 Polyclonal Antibody detects endogenous levels of ABCA6 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widely expressed with higher expression in liver,

Observed Band (KD): 185kD

Fields: ABC transporters

Function: Developmental Stage: Expressed in fetal kidney, lung and liver
Function: Probable transporter which may play a role in macrophage lipid homeostasis
Induction: Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages
Similarity: Belongs to the ABC transporter family. ABCA subfamily
Similarity: Contains 2 ABC transporter domains
Tissue Specificity: Widely expressed with higher expression in liver

Subcellular Location: Golgi apparatus membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: ABCA6

Protein Name: ATP-binding cassette sub-family A member 6

Mouse SwissProt Number: Q8K441

Research Use Only