ABCB11 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A14694-20, A14694-100
Citations, Manuals and MSDS Available upon request.
Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
Category: Polyclonal Antibodies
Applications: IF/ICC, ELISA
Cross-reactivity: Mouse, Rat
Protein Weight: 146kDa
Observed Molecular Weight: 146kDa
Immunogen: Synthetic peptide
Species: Human
GeneID: 8647
SWISS: O95342
Alternate Names: BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2; ABCB11
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Lipid Metabolism.
NCBI Alias: ABCB11
Research Use Only