ABCG2 Monoclonal Antibody - BT-MCA3431

ABCG2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3431-50, BT-MCA3431-100

Citations, Manuals and MSDS Available upon request.

Background: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.

Research Areas: Tags and cell markers, Signal transduction, Stem cells, Cancer, Metabolism

Target Protein: ABCG2

Applications: WB, ICC

Reactivity: Human, Mouse, Monkey

Clonality: Monoclonal

Clone ID: 1H2

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: ABCG2

Immunogen: Purified recombinant fragment of human ABCG2 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 72kDa

UniProt Accession: Q9UNQ0

Synonyms: MRX, MXR, ABCP, BCRP, BMDP, MXR1, ABC15, BCRP1, CD338, CDw338, EST157481, MGC102821

GeneID: 9429

Research Use Only