ABflo® 488 Rabbit anti-Human CD158 (KIR2DL1/S1/S2/S3/S5) Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A26404-100, A26404-200, A26404-500
Citations, Manuals and MSDS Available upon request.
Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Human
Protein Weight: 34kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 3810/3808/3806/3802/100132285
SWISS: Q14954/Q14953/Q14952/P43631/P43626
Alternate Names: NKAT9; CD158G；CD158A；NKAT1; CD158H; CD158J; NKAT5
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Signal Transduction Cytoskeleton / ECM Cell Adhesion Integrins BetaImmunology Cell Type Markers CD AdhesionStem Cells Hematopoietic Progenitors Lymphoid T Lymphocytic LineageStem Cells Hematopoietic Progenitors Lymphoid NK Cell LineageStem Cells Hematopoietic Progenitors Myeloid Dendritic Cell LineageStem Cells Hematopoietic Progenitors Myeloid Monocytic LineageStem Cells Hematopoietic Progenitors Myeloid Mast Cell Lineage
NCBI Alias: KIR2DL1/KIR2DS1/KIR2DS2/KIR2DS3/KIR2DS5
Modifications: Unmodified
Conjugate: ABflo® 488. Ex:491nm. Em:516nm.
Clone Number Info: ARC67708
Research Use Only