ABflo® 488 Rabbit anti-Human ErbB3/HER3 Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A24357-100, A24357-200, A24357-500
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Human
Protein Weight: 20kDa/36kDa/77kDa/141kDa/148kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 2065
SWISS: P21860
Alternate Names: ERBB3; ErbB-3; HER3; LCCS2; MDA-BF-1; c-erbB-3; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3; erb-b2 receptor tyrosine kinase 3
Source: Rabbit
Isotype: IgM
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Cancer, Tumor biomarkers, Signal Transduction, G protein signaling, Kinase, Tyrosine kinases, ErbB-HER Signaling Pathway, Cell Biology and Developmental Biology, Growth factor, EGF, Immunology and Inflammation
NCBI Alias: ErBB3
Modifications: Unmodified
Conjugate: ABflo® 488. Ex:491nm. Em:516nm.
Clone Number Info: ARC55156-IgM-01
Research Use Only