ABflo® 488 Rabbit anti-Human Integrin β5/ITGB5 Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A24246-100, A24246-200, A24246-500
Citations, Manuals and MSDS Available upon request.
Background: Ιntegrins, heterodimeric trans-membrane matrix receptors, are mainly involved in the signal transduction and attachments to extra cellular matrix (ECM).†† In ECM they act as a mediator of cell adhesion.† In human, at least 18 α and eight β subunits have been found.† ITGB5 (integrin subunit β 5) helps in facilitation of cancer cell migration, anchorage-independent growth and tumor angiogenesis. Integrin is activated by G-protein-coupled receptors, resulting in the phosphorylation of cytoplasmic domain of the β subunit. The coupled α and β cytoplasmic tails are responsible for maintaining integrin in inactive state.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Human
Protein Weight: 88kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 3693
SWISS: P18084
Alternate Names: ITGB5; integrin beta-5
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Signal Transduction, G protein signaling, G2/M DNA Damage Checkpoint, PI3K-Akt Signaling Pathway, MAPK-Erk Signaling Pathway, Cell Biology and Developmental Biology, Cell Adhesion, Cytoskeleton, Immunology and Inflammation
NCBI Alias: ITGB5
Modifications: Unmodified
Conjugate: ABflo® 488. Ex:491nm. Em:516nm.
Clone Number Info: ARC60858
Research Use Only