ABL1 Monoclonal Antibody - BT-MCA2718

ABL1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2718-50, BT-MCA2718-100

Citations, Manuals and MSDS Available upon request.

Background: ABL1: c-abl oncogene 1, receptor tyrosine kinase. The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

Research Areas: Signal Transduction, Cancer

Target Protein: ABL1

Reactivity: Human

Clonality: Monoclonal

Clone ID: 7B11D6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: ABL1

Immunogen: Purified recombinant fragment of ABL1 (aa577-650) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P00519

Synonyms: ABL, JTK7, p150, c-ABL, v-abl

GeneID: 25

Research Use Only