Product Description

Abl1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65364-50, BS65364-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: ABL proto-oncogene 1, non-receptor tyrosine kinase(ABL1) Homo sapiens This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellμlar processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regμlated by its SH3 domain, whereby deletion of the region encoding this domain resμlts in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regμlated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9, 22) translocation that resμlts in a fusion with the 5' end of the breakpoint cluster region gene (BCR, MIM:151410). Alternative splicing of this gene resμlts in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Applications: WB, IHC-p, IF(paraffin, section), ELISA

Alternate Names: ABL1, ABL, JTK7, Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: The antiserum was produced against synthesized peptide derived from human Abl. AA range:156-205

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity: Abl1 Polyclonal Antibody detects endogenous levels of Abl1 protein.

Molecular Weight: ~125 kDa

Pathway: SAPK JNK Signaling Cascades,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P00519

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only