Product Description

ACC alpha Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67437-50, BS67437-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Acetyl-CoA carboxylase (ACC) catalyzes the carboxylation of acetyl-CoA to malonyl-CoA . It is the key enzyme in the biosynthesis and oxidation of fatty acids . In rodents, the 265 kDa ACC1 (ACCα) form is primarily expressed in lipogenic tissues, while 280 kDa ACC2 (ACCβ) is the main isoform in oxidative tissues . However, in humans, ACC2 is the predominant isoform in both lipogenic and oxidative tissues . Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC . ACC is a potential target of anti-obesity drugs.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Bovine, Chicken, Sheep

Host: Rabbit

Applications: WB, IHC

Alternate Names: ACAC, ACC1, ACCA, Acetyl-CoA carboxylase 1, ACC1, ACC-alpha

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ACC alpha. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of ACC alpha protein.

Molecular Weight: ~ 280 kDa

Pathway: AMPK Signaling Pathway, Warburg Effect.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q13085

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only