Product Description

Acetyl Coenzyme A Carboxylase Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65613-50, BS65613-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Acetyl-CoA carboxylase (ACC) is a complex mμltifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regμlation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Mμltiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jμl 2008].

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Cow, Monkey

Host: Rabbit

Applications: IHC-P

Alternate Names: Acetyl Coenzyme A Carboxylase, ACAS2, AceCS, Acetate CoA ligase, Acetyl CoA synthetase, Acetyl coenzyme A synthetase cytoplasmic, Acetyl-CoA synthetase, ACS, ACSA, ACSS2, Acyl activating enzyme, Acyl CoA synthetase short chain family member 2, EC 6.2.1.1, MYH7B, ACAC, ACACB, ACC alpha, ACC beta, ACC1, ACC2, ACCA, ACCB, Acetyl CoA carboxylase 1, Acetyl CoA carboxylase 2, Acetyl CoA carboxylase alpha, Acetyl CoA carboxylase beta, Biotin carboxylase, COA1, COA2, HFA1, ACACB_HUMAN, ACACA_HUMAN, Acetyl Coenzyme A Carboxylase, Acetyl-CoA carboxylase 1, ACC1, ACC-alpha, Acetyl-CoA carboxylase 265, ACC-alpha, ACC-beta.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Acetylated

Immunogen: KLH conjugated synthetic peptide derived from human Acetyl Coenzyme A Carboxylase 1/2:2307-2355/2458

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: Acetyl Coenzyme A Carboxylase Polyclonal Antibody detects endogenous levels of Acetyl Coenzyme A Carboxylase protein.

Molecular Weight: 265kD

Pathway: Warburg Effect, AMPK Signaling Pathway,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O00763

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only