Acetyl Kine Rabbit Polyclonal Antibody - ES20844

Acetyl Kine Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES20844-50, ES20844-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Acetylation of lysine, like phosphorylation of serine, threonine or tyrosine, is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) .Signaling resulting in acetylation/deacetylation of histones, transcription factors, and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity, cell growth, differentiation, and apoptosis.Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of posttranslational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism, longevity, actin polymerization, and nuclear transport.The regulation of protein acetylation status is impaired in cancer and polyglutamine diseases, and HDACs have become promising targets for anti-cancer drugs currently in development.

Reactivity: Species independent

Host: Rabbit

Applications: WB

Alternate Names: YM3306

Clonality: Polyclonal

Immunogen: Recombinant Protein of Acetyl Kine

Isotype: IgG

Target: Acetyl Kine,

Specificity: The antibody detects endogenous Lysine Acetylated protein.

Dilution: WB: 1:1000-2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.

Formulation: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Storage and Stability: -20°C/1 year

Research Use Only