Acetyl Lys proteins Rabbit Polyclonal Antibody - ES4384

Acetyl Lys proteins Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4384-50, ES4384-100

Lead times: approximately 7-10 business days, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Acetylation of lysine, like phosphorylation of serine, threonine or tyrosine, is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Signaling resulting in acetylation/deacetylation of histones, transcription factors, and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity, cell growth, differentiation, and apoptosis. Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of posttranslational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism, longevity, actin polymerization, and nuclear transport. The regulation of protein acetylation status is impaired in cancer and polyglutamine diseases, and HDACs have become promising targets for anti-cancer drugs currently in development.

Reactivity: Human, Mouse, Rat, Monkey, plant

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Clonality: Polyclonal

Immunogen: Synthesized acetyl-peptide derived from human acetylation Lys proteins.

Isotype: IgG

Target: Acetyl Lys proteins,

Specificity: Acetyl-Lys proteins Polyclonal Antibody detects endogenous levels of acetylated Lys proteins.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Observed Band (KD): 20, 40, 80, 175kD

Storage and Stability: -20°C/1 year

Research Use Only