ACSL6 (D531) Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS3140-50, BS3140-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q9UKU0
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: IHC
All Applications: IHC:1:50~1:200
Background: Acyl-CoA synthetases, also known as long-chain fatty-acid CoA synthases (FACL) or Palmitoyl-CoA ligases, include ACSL1-6, which are all single-pass membrane proteins localizing to the mitochondrion, microsome or peroxisome.ACSL proteins are important for synthesis of cellular lipids and for β-oxidation degradation. Specifically, ACSL proteins catalyze the activation of long-chain fatty acids to acyl-CoAs, which can be metabolized to form CO2, triacylglycerol (TAG), phospholipids (PL) and cholesteryl esters (CE). ACSL6 has been shown to be an Et V6 fusion partner gene in a recurrent t(5;12) (q31;p13) translocation in a patient with refractory anemia with excess blasts (RAEB) with basophilia, a patient with acute myelogenous leukemia (AML) with eosinophilia, and a patient with acute eosinophilic leukemia (AEL).
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Immunohistochemistry (IHC) analyzes of ACSL6 (D531) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.
Bioworld Molecular Weight: ~ 78 kDa
Specificity: ACSL6 (D531) polyclonal antibody detects endogenous levels of ACSL6 protein.
Alternative Name: Long-chain-fatty-acid--CoA ligase 6; Long-chain acyl-CoA synthetase 6; LACS 6; ACSL6; ACS2; FACL6; KIAA0837; LACS5
Immunogen: Synthetic peptide, corresponding to amino acids 500-550 of Human ACSL6.
Conjugate: Unconjugated
Modification: Unmodified