ACTH Monoclonal Antibody - BT-MCA2755

ACTH Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2755-50, BT-MCA2755-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Research Areas: Others

Target Protein: ACTH

Applications: ICC, FCM

Clonality: Monoclonal

Clone ID: 3A4H4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: ACTH

Immunogen: Purified recombinant fragment of human ACTH expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 29.4kDa

UniProt Accession: P01189

Synonyms: POMC, LPH, MSH, NPP, POC, CLIP

GeneID: 5443

Research Use Only