ACVR1B (G111) Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS1988-50, BS1988-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P36896
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: IHC, IF
All Applications: IHC: 1:50~1:200
IF: 1:50~1:200
Background: Members of the transforming growth factor β superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B). Both receptor types are highly expressed in brain. The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho genesis in a dose dependent fashion.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Immunohistochemistry (IHC) analyzes of ACTR-IB (G111) pAb in paraffin-embedded human breast carcinoma tissue at 1:50,showing cytoplasmic and perinuclear staining. Negative control (the right) Using PBS instead of primary antibody,Secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.
Bioworld Molecular Weight: ~ 56 kDa
Specificity: ACTR-IB (G111) polyclonal antibody detects endogenous levels of ACTR-IB protein.
Alternative Name: Activin receptor type-1B; Activin receptor type IB; ACTR-IB; Activin receptor-like kinase 4; ALK-4; Serine/threonine-protein kinase receptor R2; SKR2; ACVR1B; ACVRLK4; ALK4
Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human ACTR-IB.
Conjugate: Unconjugated
Modification: Unmodified