Product Description

ADA Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES9364-50, ES9364-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 80-160

Isotype: IgG

Target: ADA

Specificity: ADA Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Found in all tissues, occurs in large amounts in T-lymphocytes (PubMed:20959412), Expressed at the time of weaning in gastrointestinal tissues,

Observed Band (KD): 39kD

Fields: Purine metabolism, Metabolic pathways, Nucleotide metabolism, Primary immunodeficiency

Function: Catalytic Activity: Adenosine + H(2)O = inosine + NH(3)
Disease: Defects in ADA are the cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID) [MIM: 102700]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. ADA-SCID is an autosomal recessive form accounting for about 50% of non-X-linked SCIDs. ADA deficiency has been diagnosed in chronically ill teenagers and adults (late or adult onset). Popul

Subcellular Location: Cell membrane, Peripheral membrane protein, Extracellular side Cell junction Cytoplasmic vesicle lumen Cytoplasm Lysosome Colocalized with DPP4 at the cell surface

Storage and Stability: -20°C/1 year

Gene Name: ADA ADA1

Protein Name: Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Mouse SwissProt Number: P03958

Rat SwissProt Number: Q920P6

Research Use Only