ADRM1 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-18828-60, E-AB-18828-120, E-AB-18828-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: ADRM1
Target Synonym: 110 kDa cell membrane glycoprotein; adhesion regulating molecule 1; Adhesion-regulating molecule 1; ADRM 1; Adrm1; ADRM1; ARM 1; ARM-1; ARM1; Gp110; hRpn13; M(r) 110; 000 surface antigen; Proteasomal ubiquitin receptor ADRM1; proteasome regulatory particle non ATPase 13; Proteasome regulatory particle non-ATPase 13; Regulatory particle non ATPase 13; Rpn13; Rpn13 homolog
Research Areas: Cancer, Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Application: IHC, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q16186
Background: The 26S proteasome is a key component of the ubiquitin-proteasome system, a process responsible for the majority of cellular protein degradation. hRpn13 (also termed ADRM1 or GP110) is a novel 46-kDa subunit of its 19S regulatory complex. hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity. Overexpression of hRpn13 promotes the activity of the ubiquitin-proteasome system and modulates the influence of osteoblasts on osteoclasts by controlling the stability of regulatory proteins in osteoblasts.
Concentration: 1.26 mg/mL
Immunogen: Fusion protein of human ADRM1
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method: Antigen affinity purification
Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only