AIF Monoclonal Antibody - BT-MCA2541

AIF Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2541-50, BT-MCA2541-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10

Research Areas: Others

Target Protein: AIF

Applications: WB, IHC, ICC, FCM

Reactivity: Human, Mouse, Monkey, Rat

Clonality: Monoclonal

Clone ID: 4E7

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: AIF

Immunogen: Purified recombinant fragment of human AIF expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 67kDa

UniProt Accession: O95831

Synonyms: AIFM1, AIF, PDCD8, COXPD6, MGC111425

GeneID: 9131

Research Use Only