AKAP5 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A14091-20, A14091-100
Citations, Manuals and MSDS Available upon request.
Background: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse
Protein Weight: 47kDa
Observed Molecular Weight: 47kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 9495
SWISS: P24588
Alternate Names: H21; AKAP75; AKAP79; AKAP5
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, G protein signaling, G-Protein-Coupled ReceptorsGPCR, Kinase, Neuroscience, Calcium Signaling.
NCBI Alias: AKAP5
Research Use Only