Product Description

AKT1/2 (Phospho-T308/T309) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS64584-50, BS64584-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: AKT, also known as protein kinase B (PKB), is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: AKT1 (PKB alpha), AKT2 (PKB beta) and AKT3 (PKB gamma) with AKT2 and AKT3 being approximately 82% identical with the AKT1 isoform. Each isoform has a pleckstrin homology (PH) domain, a kinase domain and a carboxy terminal regμlatory domain. AKT was originally cloned from the retrovirus AKT8, and is a key regμlator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold, overexpression or inappropriate activation of AKT has been seen in many types of cancer.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: AKT1, AKT1, AKT2, AKT3, MGC9965, Oncogene AKT1, PKB alpha, PKB, PKB beta, PKBalpha, PRKBA, PRKBB, PRKBG, Protein kinase B, Protein kinase B beta, Protein kinase B gamma, Proto-oncogene c-Akt, RAC alpha, RAC, RAC gamma, RAC PK alpha, RAC PK beta, RAC

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human AKT1/2 around the phosphorylation site of Threonine 308/Threonine 309.

Dilution: WB:1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: AKT1/2 (Phospho-T308/T309) polyclonal antibody detects endogenous levels of AKT1/2 protein only when phosphorylated at Thr308/Thr309.

Molecular Weight: ~ 55 kDa

Pathway: Phosphoinosotode Signaling, Protein Kinase C Signaling, Immune Cell Signaling, Warburg Effect, Translational Contral elF4 and p70 S6 Kinase, Insμlin &Glucose Signaling, ErbB HER Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P31749/P31751

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only