ALDH1A1 Monoclonal Antibody - BT-MCA3847

ALDH1A1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3847-50, BT-MCA3847-100

Citations, Manuals and MSDS Available upon request.

Background: ALDH1A1 is an aldehyde dehydrogenase able to oxidize a wide variety of aliphatic aldehydes (retinaldehyde, acetaldehyde, etc.) to the corresponding carboxylic acids (retinoic acid, acetic acid, etc.). ALDH1A1 (also known as RALDH1, ALDH1, or AHD2) is highly expressed in the dorsal retina, ventral midbrain (dopaminergic neurons), and hematopoietic stem cells. ALDH1A1 is involved in retinoic acid (RA) synthesis during vertebrate embryogenesis. ALDH1A1 is first detected at E9.0-E10.5 in cranial tissues (ventral mesencephalon, dorsal retina, thymic primordia, optic vesicles) and in the mesonephros. ALDH1A1 is also of interest in Parkinson's Disease (PD) being expressed in the the A9 dopaminergic (DA) neuronal group projecting to the dorsal striatum; this is the most vulnerable site in PD (Chung et al, 2005). ALDH1A1 protein is a known mesencephalic dopaminergic marker. ALDH1A1 is a cytosolic enzyme that preferentially oxidizes retinaldehyde to retinoic acid .ALDH1A1 is expressed in the epithelium of many organs, including brain, liver, testis, eye lens and cornea .ALDH1A1 is highly expressed in brain dopaminergic neurons, where it produces the retinoic acid required for their differentiation and development .The retinoic acid produced by ALDH1A1 is also important for the differentiation of hematopoietic stem cells.

Research Areas: Neuroscience, Cancer

Target Protein: ALDH1A1

Applications: WB, IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5A11

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: ALDH1A1

Immunogen: Purified recombinant fragment of human ALDH1A1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 55kDa

UniProt Accession: P00352

Synonyms: ALDC, ALDH1, PUMB1, ALDH11, RALDH1, ALDH-E1, MGC2318, ALDH1A1

GeneID: 216

Research Use Only