Alpha-2-Macroglobulin (A2M) Rabbit pAb - A16336

Alpha-2-Macroglobulin (A2M) Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A16336-20, A16336-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.

Category: Polyclonal Antibodies

Applications: WB, IHC-P, ELISA

Cross-reactivity: Human

Protein Weight: 163kDa

Observed Molecular Weight: Refer to figures

Immunogen: Recombinant protein (or fragment)

Species: Human

GeneID: 2

SWISS: P01023

Alternate Names: A2MD; CPAMD5; FWP007; S863-7; Alpha-2-Macroglobulin (A2M)

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:2000 IHC-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Cell Biology Developmental Biology, Ubiquitin, Cardiovascular, Blood, Serum Proteins.

NCBI Alias: A2M

Research Use Only