Product Description

Alpha-internexin Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67113-50, MB67113-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Alpha-internexin is a class-IV neuronal intermediate filament that is involved in morphogenesis of neurons and is localized mostly in synaptic vesicles, primarily found in the post-synaptic compartment where it modμlates neurotransmission function by interacting with different neurotransmitter receptors. Alpha-internexin interacts with tubμlin and actin, suggesting its role in axonal transport and stabilization of dendrites. Expression of Alpha-internexin occurs in embryonic stages in rat at E10 in the cortex, auditory ganglion, olfactory epithelial, spinal cord and brainstem, and expression also occurs in postnatal stages in the cerebellum in mice and humans. Alpha-internexin expression is altered in different neurological diseases and disorders, where it decreases in bipolar disorder and increases in schizophrenia and Alzheimer's disease. Some of these findings were generated by proteomic analysis from Alzheimer's disease and control brains. The overexpression of Alpha-internexin enhances the neurite outgrowth during neuronal growth factor induction, induces the activation caspase-3, which triggers apoptosis and eventually neuronal death. Alpha-internexin coμld be playing a role in drug addiction, where chronic cocaine exposure decreases the levels of the protein, but not with morphine exposure, suggesting the possibility to interact with different receptors.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Mouse

Applications: WB, IHC, IF/ICC

Alternate Names: NEF5, Alpha-internexin, Alpha-Inx, 66 kDa neurofilament protein, NF-66, Neurofilament-66, Neurofilament 5

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Alpha-internexin. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/10 - 1/50)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of Alpha-internexin protein.

Molecular Weight: ~ 58 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q16352

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only