AMACR Monoclonal Antibody - BT-MCA3651

AMACR Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3651-50, BT-MCA3651-100

Citations, Manuals and MSDS Available upon request.

Background: AMACR (alpha-methylacyl-CoA racemase) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. AMACR can be used as a positive marker for PIN. Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4); also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.

Research Areas: Epigenetics and nuclear signaling, Metabolism, Cancer, Tags and, cell markers

Target Protein: AMACR

Applications: WB, IHC, ICC

Reactivity: Human, Mouse

Clonality: Monoclonal

Clone ID: 2A10F3

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: AMACR

Immunogen: Purified recombinant fragment of human AMACR expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 42kDa

UniProt Accession: Q9UHK6

Synonyms: RACE

GeneID: 23600

Research Use Only