AMHR2 Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: BS6322-50, BS6322-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: MISR II (anti-Muellerian hormone type-2 receptor, MIS type II receptor) is a 573 amino acid protein encoded by the human gene AMHR2. MISR II belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily and contains one protein kinase domain. Upon ligand binding, MISR II forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. These type II receptors phospho-rylate and activate type I receptors which autophosphorylate, then bind and activate Smad transcriptional regμlators. MISR II also acts as a receptor for anti-Muellerian hormone. Defects in AMHR2 are the cause of persistent Muellerian duct syndrome type 2 (PMDS-2). PMDS-2 is a form of male pseudo-hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males. Category: Primary Antibody Reactivity: Human Host: Rabbit Applications: WB, ELISA Alternate Names: Anti-Muellerian hormone type-2 receptor, Anti-Muellerian hormone type II receptor, AMH type II receptor, MIS type II receptor, MISRII, MRII, AMHR2, AMHR, MISR2 Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: KLH conjugated synthetic peptide derived from human MISRII/AMHR2: 21-120/573 Dilution: WB 1:500 - 1:2000 ELISA 1:5000 - 1:10000 Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Specificity: AMHR2 polyclonal antibody detects endogenous levels of AMHR2 protein. Molecular Weight: ~ 63 kDa Pathway: TGFβ Smad signaling, Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: Q16671 Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Research Use Only