Angiotensin II type 1A receptor Polyclonal Antibody Sizes: 50µl, 100µl Catalogue Numbers: BS65523-50, BS65523-100 Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Swiss-Prot: P30556 Host: Rabbit Reactivity: Human, Mouse, Rat, Applications: WB, All Applications: WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Background: The Angiotensin II type 1 receptor (AT1) is the primary effector of Angiotensin II, a key regulator of blood pressure and fluid homeostasis. It is involved in pathogenesis of several cardiovascular diseases such as hypertension, cardiac hypertrophy and congestive heart failure. Angiotensin II interacts with two types of G-protein coupled membrane receptors, AT1 (type 1) and AT2 (type 2). AT1 has three isoforms in rodents: AT1A (359 aa), AT1B (359 aa), and AT1C (177 aa). Rat AT1's are predicted to contain seven transmembrane domains. The N-terminus is predicted to be extracellular, while the C-terminus is predicted to be cytoplasmic. AT1's are expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal and vascular smooth muscle. Purification and Purity: affinity purified by Protein A Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity: Angiotensin II type 1A receptor polyclonal Antibody detects endogenous levels of Angiotensin II type 1A receptor protein. Bioworld Molecular Weight: ~41kDa Note: For research use only, not for use in diagnostic procedure. Extra Notes: Anti-Angiotensin II type 1A receptor at 1/1000 dilution, Anti-Angiotensin II type 1A receptor at 1/500 dilution, Anti-Angiotensin II type 1A receptor at 1/1000 dilution, Anti- Angiotensin II type 1A receptor at 1/1000 dilution Alternative Name: AGTR1; Agtr1a; AT1; AT1A; AT1AR; Type 1 angiotensin II receptor; AGTR1_HUMAN; AGTR1B; AT2R1; AT2R1B. Immunogen: KLH conjugated synthetic peptide derived from human Angiotensin II type 1A receptor:101-200/359 Conjugate: Unconjugated Modification: Unmodified