Angiotensin II type 1A receptor Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: BS65523-50, BS65523-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: The Angiotensin II type 1 receptor (AT1) is the primary effector of Angiotensin II, a key regμlator of blood pressure and fluid homeostasis. It is involved in pathogenesis of several cardiovascμlar diseases such as hypertension, cardiac hypertrophy and congestive heart failure. Angiotensin II interacts with two types of G-protein coupled membrane receptors, AT1 (type 1) and AT2 (type 2). AT1 has three isoforms in rodents: AT1A (359 aa), AT1B (359 aa), and AT1C (177 aa). Rat AT1's are predicted to contain seven transmembrane domains. The N-terminus is predicted to be extracellμlar, while the C-terminus is predicted to be cytoplasmic. AT1's are expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal and vascμlar smooth muscle. Category: Primary Antibody Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB Alternate Names: AGTR1, Agtr1a, AT1, AT1A, AT1AR, Type 1 angiotensin II receptor, AGTR1_HUMAN, AGTR1B, AT2R1, AT2R1B. Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: KLH conjugated synthetic peptide derived from human Angiotensin II type 1A receptor:101-200/359 Dilution: WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations shoμld be determined by the end user. Purification: affinity purified by Protein A Specificity: Angiotensin II type 1A receptor polyclonal Antibody detects endogenous levels of Angiotensin II type 1A receptor protein. Molecular Weight: ~41kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: P30556 Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Research Use Only