Product Description

Annexin II (phospho Ser26) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES5716-50, ES5716-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: ANXA2, ANX2, ANX2L4, CAL1H, LPC2D, Annexin A2, Annexin II, Annexin-2, Calpactin I heavy chain, Calpactin-1 heavy chain, Chromobindin-8, Lipocortin II, Placental anticoagulant protein IV, PAP-IV, Protein I, p36

Clonality: Polyclonal

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Annexin II (phospho Ser26)

Isotype: IgG

Target: Annexin II

Specificity: Phospho-Annexin II (S26) Polyclonal Antibody detects endogenous levels of Annexin II protein only when phosphorylated at S26.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Colon, Colon adenocarcinoma, Epithelium, Osteosarcoma, Pancreas, Placenta, Prostate, Skin, Te

Observed Band (KD): 38kD

Fields: Salmonella infection

Function: Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid
Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response
Miscellaneous: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis
Online Information: Red velvet - Issue 86 of September 2007,PTM: Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface
Similarity: Belongs to the annexin family
Similarity: Contains 4 annexin repeats
Subcellular Location: In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism
s

Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane Melanosome In the lamina beneath the plasma membrane Identified by mass spectrometry in melanosome fractions from stage I to stage IV Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism

Storage and Stability: -20°C/1 year

Gene Name: ANXA2

Protein Name: Annexin A2

Mouse Gene ID: 12306

Mouse SwissProt Number: P07356

Rat Gene ID: 56611

Rat SwissProt Number: Q07936

Research Use Only