Product Description

Anti-Human MS4A1 & CD3E Bispecific Reference Antibody (Glofitamab, RUO)

Sizes: 100ug, 1mg

Catalogue Numbers: HY257146-100, HY257146-1000

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Description: Glofitamab is a T-cell-engaging bispecific antibody possessing a novel 2:1 structure with bivalency for CD20 on B cells and monovalency for CD3 on T cells. Glofitamab is an investigational, T-cell bispecific antibody with a distinctive design that features 2 Fab arms for binding CD20 on B cells, along with 1 Fab arm for binding CD3 on T cells. The CD3 binding arm is fused directly to one of the CD20-binding arms in a head-to-tail fashion via a short flexible linker.

Reactivity: Human

Host: Humanized

Applications: ELISA, Bioactivity: FACS, Functional assay

Alternate Names: Bispecific, CD20-TCB (2:1), RG-6026, 2229047-91-8

Clonality: Monoclonal

Isotype: IgG1-kappa-lambda

Target: B-lymphocyte surface antigen B1, Membrane-spanning 4-domains subfamily A member 1, MS4A1, Leukocyte surface antigen Leu-16, B-lymphocyte antigen CD20, Bp35, CD20, T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain

Purification: Protein A/G purified from cell culture supernatant.

Purity: >95% as determined by SDS-PAGE.

Expression System: Mammalian Cells

Storage and Stability: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Storage Buffer: 0.01M PBS, pH 7.4.

Form: Liquid

Accession: P11836 & P07766

Endotoxin Level: Contact Us for more information.

Research Use Only