APBB1 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA31127-50, RA31127-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: amyloid beta precursor protein binding family B member 1 (APBB1) Homo sapiens The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012], Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, ELISA Clonality: Polyclonal Dilution: WB 1:500-2000 ELISA 1:5000-20000 Molecular Weight: 78 Protein Molecular Weight (kDa): 78 Storage: -20°C/1 year Human Gene ID: 322 Human SwissProt Number: O00213 Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Research Use Only