Product Description

APC (phospho-S2054) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4649-50, BS4649-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Adenomatous polyposis coli (APC) is a protein that plays a critical role in several cellμlar processes. APC is a tumor suppressor, regμlates cell division, helps ensure that the number of chromosomes in a cell is correct following cell division and associates with other proteins involved in cell attachment and signaling. APC regμlates ß-catenin levels through Wnt-signaling and is involved in actin cytoskeletal integrity, cell-cell adhesion and cell migration. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and resμlt in a truncated protein product.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 2.5, APC, DP2.5

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human APC around the phosphorylation site of Serine 2054.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-APC (S2054) polyclonal antibody detects endogenous levels of APC protein when phosphorylated at Ser2054.

Molecular Weight: ~ 310 kDa

Pathway: Regμlation of Microtubμle Dynamics, Contribution of Soluble Factors to EMT,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P25054

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only