ApoB Monoclonal Antibody - BT-MCA2319

ApoB Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2319-50, BT-MCA2319-100

Citations, Manuals and MSDS Available upon request.

Background: This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.

Research Areas: Epigenetics and nuclear signaling, Immunology

Target Protein: ApoB

Applications: ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 6G6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: ApoB

Immunogen: Purified recombinant fragment of human ApoB expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 516kDa

UniProt Accession: P04114

Synonyms: FLDB, LDLCQ4

GeneID: 338

Research Use Only