ApoE Monoclonal Antibody - BT-MCA2960

ApoE Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2960-50, BT-MCA2960-100

Citations, Manuals and MSDS Available upon request.

Background: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Tissue specificity: Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.

Research Areas: Neuroscience, Cardiovascular

Target Protein: ApoE

Applications: IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1H4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: ApoE

Immunogen: Purified recombinant fragment of human ApoE expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 36kDa

UniProt Accession: P02649

Synonyms: AD2, LPG, LDLCQ5, MGC1571

GeneID: 348

Research Use Only